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Amplia Therapeutics Limited (ASX: ATX), (“Amplia” or the “Company”), is pleased to announce important new data from our ongoing ACCENT clinical trial in pancreatic cancer. The trial is investigating the Company’s best-in-class FAK inhibitor narmafotinib in combination with standard-of-care chemotherapies gemcitabine and Abraxane. Fifteen (15) confirmed partial responses (PRs) have now been recorded in the trial, a level of response sufficient to demonstrate that the combination of narmafotinib and chemotherapy is superior to chemotherapy alone.

HIGHLIGHTS

  • Key milestone achieved, with 15 confirmed responses recorded in the ongoing Phase 1b/2a ACCENT trial
  • Sufficient confirmed responses have now been recorded to demonstrate that narmafotinib combined with chemotherapy is superior to chemotherapy alone.
  • The ACCENT trial is evaluating narmafotinib in combination with the chemotherapies gemcitabine and Abraxane® in patients with advanced pancreatic cancer
  • Narmafotinib is a highly potent and selective FAK inhibitor discovered at the Melbourne-based Cooperative Research Centre for Cancer Therapeutics.
  • Phase 2a ACCENT trial is fully recruited with top-line data expected in mid Q3 2025

A confirmed partial response is a formal designation of response where tumour shrinkage >30% is recorded and sustained for two (2) or more months and where no new cancerous lesions have been detected. As pancreatic cancer is highly aggressive it is extremely rare for patients to achieve a complete response (CR).

The ACCENT trial is an open-label study meaning that all patients on the study receive narmafotinib in combination with the standard-of-care therapy. The data obtained in this trial is compared to historical data for the combination of gemcitabine and Abraxane in pancreatic cancer, and specifically data from the MPACT study, upon which we have closely modelled our trial1.

At the outset of the study a statistical analysis was performed which identified that a patient cohort of 50 patients would be sufficient to allow the efficacy of our combination to be ascertained with reasonable confidence if 15 or more responders (confirmed PR or CR) were recorded. A total of 55 advanced pancreatic patients have enrolled in the study since January 2024, with 21 patients still on study at this time.

As noted in our recent press release2, the drug continues to be well tolerated by patients with the rate and type of adverse events for the narmafotinib combination being similar to that reported for chemotherapy alone.

Amplia CEO and MD Dr Chris Burns commented: “We are extremely excited to have now recorded 15 confirmed partial responses in the ACCENT trial, demonstrating the benefit of adding narmafotinib to standard-of-care chemotherapy. With over 20 patients still on study we are hopeful that further PR’s will be observed”

Click here for the full ASX Release

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Eric Nuttall, partner and senior portfolio manager at Ninepoint Partners, shares his outlook for oil and natural gas, honing in on supply, demand and prices.

Global uncertainty has placed pressure on the oil market, and Nuttall said for that reason he sees natural gas stocks outperforming oil stocks in the near term.

Securities Disclosure: I, Charlotte McLeod, hold no direct investment interest in any company mentioned in this article.

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Tolu Minerals Limited (“Tolu”) is pleased to announce the granting of its Ipi River tenement EL 2780 (Figure 1) covering 395.56 km2 of highly prospective copper-gold mineralisation. The historically discovered Ipi River porphyry deposit within EL 2780, located 55 km northwest of the Tolukuma gold mine is one of several under-explored porphyry style Cu-Au-Mo systems with epithermal Au overprint within Tolu’s exploration portfolio.

HIGHLIGHTS:

  • Ipi River tenement EL2780 granted by the Mineral Resource Authority
  • Preliminary interpretation of Airborne MT imagery indicates five previously unknown copper-gold targets that require further exploration and drill testing
  • The newly advanced Airborne MT survey provides electrical resistivity imaging of the top 1km to define geological targets and structures related to copper-gold mineralisation, as well as magnetic data to assist in the exploration process
  • Ipi River Porphyry System represents a historically under-explored Cu-Au-Mo system where previous rock sampling results returned up to 10.10% copper and 167g/t gold
  • Douglas Kirwin, renowned porphyry and epithermal specialist, is appointed to the Advisory Board
Iain Macpherson, MD & CEO of Tolu Minerals Ltd. said:

“I’m pleased to report the progression of our exploration strategy with the award of Exploration License EL 2780 consisting of highly prospective ground within the Ipi River tenement. This award, coupled with our recent and historical exploration programmes at Ipi River, reinforces Tolu’s position as an emerging, important explorer and operator in what is rapidly becoming one of the great gold/copper provinces of the world.

Recently flown Airborne MT preliminary imagery reinforces historical exploration data and indicates a number of porphyry or intrusive related copper-gold targets. The tenement also includes historical copper-gold-molybdenum, late-stage epithermal gold, and peripheral unexplored Au targets. This latest addition to our tenement portfolio allows us to proceed with our next stage of exploration on a more detailed evaluation of the Airborne MT results and target areas.

The award of the Ipi River exploration license is a significant addition to Tolu’s highly prospective exploration and development portfolio that provides a number of compelling targets and potential for further major discoveries.

In line with the Company’s vision to reveal the porphyry and epithermal deposit potential at Tolukuma, Mt Penck and now Ipi River, the appointment of Doug Kirwin to Tolu’s Advisory Board is a testament to the Company’s broader commitment to defining a substantial resource within Tolu’s exploration targets, further to the re-start of the Tolukuma Gold-Silver Mine.”

Chris Muller, Tolu’s Executive Group Geologist commented that “the continuous progress towards growing Tolu’s exploration portfolio with high potential tenements has reinforced my view that Tolu is among the most exciting growth companies in one of the great underdeveloped and underexplored gold mining provinces on the planet.”

The advanced Airborne Magneto Telluric (“Airborne MT” or “MT”) survey was flown over the Eastern 209km2 of the EL to help in identifying a new generation of geophysical targets related to gold and copper-lead-zinc mineralisation for ground follow-up and drilling.

Airborne MT is an advanced geophysical technology providing high-resolution, deep resistivity/conductivity 3D mapping to over 1km depth. Final data from the recently completed airborne MT survey flown over the known Ipi River porphyry and Mt. Yule “Bulls- eye” magnetic porphyry gold-copper systems have diagnostic sub-surface conductivity, resistivity and magnetic signatures that are calibrations for identifying similar integrated anomalies.

An additional five, previously unexplored discrete geophysical target areas, have already been identified, proving the technique to be a cost-effective compliment to historical exploration results. A more detailed desktop review of historical exploration and airborne geophysics will now be completed ahead of fieldwork on ground.

Target mineralisation within the tenement includes an extremely intense and large 6km x 6km dipolar “Bulls-eye” magnetic anomaly (Figure 2) at Mt. Yule (IPI06), located at a major structural intersection of the NE-trending Yule Transfer Structure and orthogonal structure related to a deep-set high electrical resistivity trend (Figure 3).

The IPI06 occurs as an exceptionally high magnetic signature (>1,730nT dipolar variation) and geologically related to a diorite/monzonite intrusive. The magnetic characteristics are like that of the Indonesia Grasberg monzodiorite and Ertsberg diorite Cu-Au-Ag mineral deposits, located on the Western half of New Guinea island1.

Click here for the full ASX Release

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Saga Metals Corp. (‘SAGA’ or the ‘Company’) (TSXV: SAGA) (OTCQB: SAGMF) (FSE: 20H) a North American exploration company specializing in the discovery of critical minerals, is pleased to announce the appointment of Vernon Shein to its board of advisors.

A mining industry veteran with 39 years of exploration industry experience, Mr. Shein spent the last 18 years as Exploration Manager for Bema Gold Corp. and its successor company B2Gold, specializing in advancing exploration programs through Preliminary Economic Assessment, Feasibility Study and into production.

Mr. Shein holds a B.Sc., Specialization Geology, from Concordia University and has conducted exploration programs on gold and base metals projects located throughout Canada, South America, Russia and the Asia Pacific. While serving as Exploration Manager at B2Gold, projects that he has managed from exploration through to production include the Kupol Mine in Russia, the Jabali Mine in Nicaragua and the Montana open pit at the Masbate Mine in the Philippines. At the Kupol Mine, Mr. Shein oversaw the drilling and modeling of the deposit through Pre-Economic Assessment in 2004 and Final Feasibility in 2005. Mr. Shein also developed the Jabali Mine from an untested, previously mined prospect to a mineable reserve/resource in two years with mining commencing in 2013. In recent years, Mr. Shein oversaw exploration activities at the Masbate Mine which developed new reserves at the Montana and Pajo deposits. He also oversaw exploration at the Aurion/B2GOLD joint venture in Central Lapland, Finland, resulting in the discovery of the western extension of Rupert’s Ikkari deposit.

‘We are thrilled to welcome Vern to SAGA’s board of advisors,’ stated Mike Stier, CEO & Director of Saga Metals . ‘Vern’s industry insight will be valuable across our entire suite of prospective critical mineral projects with initial focus spent on the Radar Ti-V-Fe project near Cartwright, Labrador. With the exceptional results to date from our maiden drill program and the ability to fast track this project, building a board of technically proficient advisors with world class experience is paramount to our success. The Radar project is poised for advanced development and we’re fortunate to have Vern’s expertise as a sounding board as we move through these critical next steps.’

Mr. Shein commented: ‘I am excited to be advising Saga Metals Corp. with their intelligent, diversified and aggressive exploration programs targeting critical minerals that support the green energy transition.   Given my successful advancement of several projects from grass roots through to production, I’m eager to add value to SAGA’s rapidly evolving Radar Ti-V-Fe project.’

About Saga Metals Corp.

Saga Metals Corp. is a North American mining company focused on the exploration and discovery of critical minerals that support the global transition to green energy. The company’s flagship asset, the Double Mer Uranium Project, is located in Labrador, Canada, covering 25,600 hectares. This project features uranium radiometrics that highlight an 18km east-west trend, with a confirmed 14km section producing samples as high as 0.428% U 3 O 8 and uranium uranophane was identified in several areas of highest radiometric response (2024 Double Mer Technical Report).

In addition to its uranium focus, SAGA owns the Legacy Lithium Property in Quebec’s Eeyou Istchee James Bay region. This project, developed in partnership with Rio Tinto, has been expanded through the acquisition of the Amirault Lithium Project. Together, these properties cover 65,849 hectares and share significant geological continuity with other major players in the area, including Rio Tinto, Winsome Resources, Azimut Exploration, and Loyal Lithium.

SAGA also holds additional exploration assets in Labrador, where the company is focused on the discovery of titanium, vanadium, and iron ore. With a portfolio that spans key minerals crucial to the green energy transition, SAGA is strategically positioned to play an essential role in the clean energy future.

On Behalf of the Board of Directors

Mike Stier, Chief Executive Officer

For more information, contact:
Saga Metals Corp.
Investor Relations
Tel: +1 (778) 930-1321
Email: info@SAGAmetals.com
www.SAGAmetals.com

The TSX Venture Exchange has not reviewed and does not accept responsibility for the accuracy or adequacy of this release. Neither the TSX Venture Exchange nor its Regulation Service Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Cautionary Disclaimer

This news release contains forward-looking statements within the meaning of applicable securities laws that are not historical facts. Forward-looking statements are often identified by terms such as ‘will’, ‘may’, ‘should’, ‘anticipates’, ‘expects’, ‘believes’, and similar expressions or the negative of these words or other comparable terminology. All statements other than statements of historical fact, included in this release are forward-looking statements that involve risks and uncertainties. In particular, this news release contains forward-looking information pertaining to the Company’s advisors and projects. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Important factors that could cause actual results to differ materially from the Company’s expectations include, but are not limited to, changes in the state of equity and debt markets, fluctuations in commodity prices, delays in obtaining required regulatory or governmental approvals, environmental risks, limitations on insurance coverage, risks and uncertainties involved in the mineral exploration and development industry, and the risks detailed in the Company’s final prospectus in Manitoba and amended and restated final prospectus for British Columbia, Alberta and Ontario dated August 30, 2024, filed under its SEDAR+ profile at www.sedarplus.ca, and in the continuous disclosure filings made by the Company with securities regulations from time to time. The reader is cautioned that assumptions used in the preparation of any forward-looking information may prove to be incorrect. Events or circumstances may cause actual results to differ materially from those predicted, as a result of numerous known and unknown risks, uncertainties, and other factors, many of which are beyond the control of the Company. The reader is cautioned not to place undue reliance on any forward-looking information. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement. The forward-looking statements contained in this news release are made as of the date of this news release and the Company will update or revise publicly any of the included forward-looking statements only as expressly required by applicable law.

News Provided by GlobeNewswire via QuoteMedia

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American Salars Lithium Inc. (‘AMERICAN SALARS’ OR THE ‘COMPANY’) (CSE: USLI, OTC: ASALF, FWB: Z3P, WKN: A3E2NY ) announces the addition of Dr. Mark King PhD, PGeo, FGC, a world-renowned lithium brine expert, as a Technical Advisor and Qualified Person.

Dr. King is a hydrogeologist with 30+ years of international experience in groundwater modeling and geochemistry. For the past 15 years, he has specialized in exploration and evaluation of lithium brine projects. His strong chemistry and numerical modeling background has proven to be an excellent foundation for brine exploration and quantitative evaluation. Consequently, his resource and reserve estimation experience on major brine projects is now arguably the most extensive of any geologist, hydrogeologist, or engineer in the world.

Some notable past involvements include serving as a resource and/or reserve estimation Qualified Person for the following:

  • Albermarle at Salar Atacama (Chile), Silver Peak (Nevada, USA) and Antofalla Salar (Argentina)
  • Neo Lithium at the 3Q Salar, (Argentina)
  • Lithium Americas at the Cauchari Salar, (Argentina)
  • Vulcan Energy in the Rhine Valley, (Germany)
  • Alpha Lithium at Tolillar & Hombre Muerto Salar, (Argentina)

In addition, Dr. King and his team have conducted detailed due diligence reviews of 20+ advanced brine projects and reconnaissance reviews (and ranking) of 100+ greenfield to early-stage projects, in South America and the southern US. His technical team at GWI have advanced expertise in geological modelling, GIS, data management and 3D visualization. They will provide exploration and resource consulting services to American Salars from time to time.

R. Nick Horsley, CEO & Director States , ‘American Salars is yet again adding depth to its technical team. We are fortunate to welcome Dr. King and his team at GWI to American Salars and look forward to working together in our search for significant lithium salar projects. Mark is a globally recognized authority whose work has taken him to lithium brine projects throughout North and South America, and beyond.’

About American Salars Lithium Inc.

About American Salars Lithium Inc. American Salars Lithium Inc. is an exploration company focused on exploring and developing high-value battery metals projects to meet the demands of the advancing electric vehicle market.

All Stakeholders are encouraged to follow the Company on its social media profiles on LinkedIn, Twitter and Instagram.

On Behalf of the Board of Directors,

‘R. Nick Horsley

R. Nick Horsley, CEO

For further information, please contact:

American Salars Lithium Inc.
‎Phone: 604.880.2189
‎E-Mail: info@americansalars.com

Neither the Canadian Securities Exchange nor its Regulation Services Provider (as that term is defined in the policies of the CSE) accepts responsibility for the adequacy or accuracy of this release.

Disclaimer for Forward-Looking Information

Certain statements in this release are forward-looking statements, which reflect the expectations of management regarding American Salar’s intention to continue to identify potential transactions and make certain corporate changes and applications. Forward looking statements consist of statements that are not purely historical, including any statements regarding beliefs, plans, expectations, or intentions regarding the future. Such statements are subject to risks and uncertainties that may cause actual results, performance, or developments to differ materially from those contained in the statements. No assurance can be given that any of the events anticipated by the forward-looking statements will occur or, if they do occur, what benefits American Salars will obtain from them. These forward-looking statements reflect managements’ current views and are based on certain expectations, estimates and assumptions which may prove to be incorrect. A number of risks and uncertainties could cause actual results to differ materially from those expressed or implied by the forward-looking statements, including American Salars results of exploration or review of properties that American Salars does acquire. These forward-looking statements are made as of the date of this news release and American Salars assumes no obligation to update these forward-looking statements, or to update the reasons why actual results differed from those projected in the forward-looking statements, except in accordance with applicable securities laws.


News Provided by GlobeNewswire via QuoteMedia

This post appeared first on investingnews.com

American Eagle on Tuesday said it is writing off $75 million in spring and summer merchandise and withdrawing its full-year guidance as it contends with slow sales, steep discounting and an uncertain economy.

The apparel retailer said it expects revenue in the first quarter, which ended in early May, to be around $1.1 billion, a decline of about 5% compared to the prior-year period. American Eagle anticipates comparable sales will drop 3%, led by an expected 4% decline at intimates brand Aerie. American Eagle previously expected first-quarter sales to be down by a mid-single-digit percentage and anticipated full-year sales would drop by a low single-digit percentage. 

Shares plunged more than 17% in extended trading. 

When it reported fiscal fourth-quarter results in March, American Eagle warned that the first quarter was off to a “slower than expected” start, due to weak demand and cold weather. Conditions evidently worsened as the quarter progressed, and the retailer turned to steep discounts to move inventory.

As a result, American Eagle is expecting to see an operating loss of around $85 million and an adjusted operating loss, which cuts out one-time charges related to its restructuring, of about $68 million for the quarter. That loss reflects “higher than planned” discounting and a $75 million inventory charge related to a write-down of spring and summer merchandise, the company said. 

“We are clearly disappointed with our execution in the first quarter. Merchandising strategies did not drive the results we anticipated, leading to higher promotions and excess inventory. As a result, we have taken an inventory write down on spring and summer goods,” said CEO Jay Schottenstein.

“We have entered the second quarter in a better position, with inventory more aligned to sales trends,” he said. “Additionally, we are actively evaluating our forward plans. Our teams continue to work with urgency to strengthen product performance, while improving our buying principles.” 

The company added it is withdrawing its fiscal 2025 guidance “due to macro uncertainty and as management reviews forward plans in the context of first quarter results.” It is unclear if recent tariff policy changes had an effect on American Eagle.

Some companies bought inventory earlier than usual to plan for higher duties, but American Eagle repeatedly said in March that it was in a solid inventory position and was able to go after trends as customer preferences shifted. 

At the start of the first quarter, the company said it had some inventory outages and needed to supplement stock in a few key categories, particularly at Aerie, one of its primary growth drivers. 

This post appeared first on NBC NEWS

Uber is giving commuters new ways to travel and cut costs on frequent rides.

The ride-hailing company on Wednesday announced a route share feature on its platform, prepaid ride passes and special deals week for Uber One members at its annual Go-Get showcase.

Uber’s new features come as the company accelerates its leadership position in the ride-sharing market and seeks to offer more affordable alternatives for users. It also follows last week’s first-quarter earnings as Uber swung to a profit but fell short of revenue estimates.

“The goal for us as we build our products is to put people at the center of everything, and right now for us, it means making things a little easier, a little more predictable, and above all, just a little more — or a lot more — affordable,” said Uber CEO Dara Khosrowshahi at the event.

Here are some of the big announcements from the annual product event.

Users looking to save money on regular routes and willing to walk a short distance can select a shared ride with up to two other passengers through the new route-share feature.

The prepopulated routes run every 20 minutes along busy areas between 6 a.m. and 10 a.m. and 4 p.m. and 8 p.m. on weekdays. The initial program is slated to kick off in seven cities, including New York, San Francisco, Boston and Chicago.

Uber said its new route-share fares will cost up to 50% less than an UberX option, and that it is working to partner with employers on qualifying the feature for commuter benefits. Users can book a seat from 7 days to 10 minutes before a pickup departure.

Riders on Uber can now prepurchase two different types of ride passes to hold fares on frequented routes during a one-hour period every day. For $2.99 a month, riders can buy a price lock pass that holds a price between two locations for one hour every day. The pass expires after 30 days or a savings total of $50.

The feature gives riders a way to avoid surge pricing.

Ride Passes roll out in 10 cities on Wednesday, including Dallas, Orlando and San Francisco, and can be purchased for up to 10 routes a month. Uber will charge users a lower price if the fare is cheaper than the pass at departure time.

The company also debuted a prepaid pass option, allowing users to pay in advance and stock up on regular monthly trips. Uber’s pass option comes in bundles of 5, 10, 15 and 20-ride increments, with corresponding discounts between 5% and 20%.

Both pass options will be available on teen accounts in the fall, Uber said. The route share and ride passes will be available in a new commuter hub feature on the app coming later this year.

Uber is also expanding its autonomous vehicle partnership with Volkswagen.

The company will start testing shared AV rides later this year and is aiming for a launch in Los Angeles in 2026.

Uber rolled out autonomous rides in Austin, Texas, in March through its agreement with Alphabet-owned Waymo and is preparing for an Atlanta launch this summer. The company announced the partnership in May 2023. Autonomous Waymo rides are also currently offered through the Uber app in Phoenix, but the company does not directly manage that fleet.

Khosrowshahi called AVs “the single greatest opportunity ahead for Uber” during the company’s earnings call last week and said the Austin debut “exceeded” expectations. The company previously had an AV unit that it sold in 2020 as it faced high costs and a series of safety challenges, including a fatal accident.

Along with Volkswagen and Waymo, Uber has joined forces with Avride, May Mobility and self-driving trucking company Aurora for autonomous ride-sharing and freight services in the U.S. The company has partnerships with WeRide, Pony.AI and Momenta internationally.

Uber is taking a page out of Amazon’s book by offering its own variation of the e-commerce giant’s beloved Prime Day, with special offers between May 16 and 23 for Uber One members.

Some of those deals include 50% off shared rides and 20% off Uber Black. The platform is also adding a new benefit of 10% back in Uber credits for users that use Uber Rent or book Lime rides.

UberEats also announced a partnership with OpenTable to allow users to book reservations and rides.

The new feature, powered by OpenTable, launches in six countries including the U.S. and Australia.

Through the partnership, users can book restaurant reservations and get a discount on rides. OpenTable members will also be able to transfer points to Uber and UberEats. The company is also offering OpenTable VIPs a six-month free trial of Uber One.

This post appeared first on NBC NEWS

YouTube will stream the National Football League’s Week 1 game on Sept. 5 for free, the first time the dominant streaming platform has ever broadcast a live NFL game in its entirety.

The game, which Front Office Sports first reported will be between the Kansas City Chiefs and the Los Angeles Chargers, will take place in Sao Paulo, Brazil.

“Last year, people spent over 350 million hours watching official NFL content on YouTube, so it’s both fitting and thrilling to continue to build our relationship with our partners at the NFL,” YouTube Chief Business Officer Mary Ellen Coe said in a statement. “Streaming the Friday night game to fans for free around the world will mark YouTube’s first time as a live NFL broadcaster — and we’ll do it in a way that only YouTube can, with an interactive viewing experience and creators right at the center of the experience.”

The game will be available to all YouTube and YouTube TV users globally, except in Canada and certain other countries, and locally on broadcast television in the media markets of the participating teams, YouTube said in a statement.

YouTube is the most-watched streaming platform in the U.S., consisting of 12% of all viewership for March, according to Nielsen.

The NFL has an existing deal with YouTube TV for Sunday Ticket, the league’s out-of-market package of games. Those games require a subscription — either $480 per year without YouTube TV or $378 per year for YouTube TV subscribers. YouTube TV is a collection of linear TV networks that approximates a standard cable bundle.

The full 2025 NFL schedule will be released Wednesday at 8 p.m. ET.

This post appeared first on NBC NEWS

In this in-depth walkthrough, Grayson introduces the brand-new Market Summary Dashboard, an all-in-one resource designed to help you analyze the market with ease, speed, and depth. Follow along as Grayson shows how to take advantage of panels, mini-charts, and quick scroll menus to maximize your StockCharts experience.

This video originally premiered on May 12, 2025. Click on the above image to watch on our dedicated Grayson Roze page on StockCharts TV.

You can view previously recorded videos from Grayson at this link.

Bullish signal alert! Over 50% of S&P 500 stocks are now above their 200-day moving average.

In this video, Dave explains this key market breadth indicator and what it means for stock market trends. He shows how moving average breadth has reached a bullish milestone, what this means based on historical signals over the past 15 years, and how it compares to the Zweig Breadth Thrust. He also introduces the stoplight market phase technique—a simple but effective method using StockCharts tools to assess market conditions in real time.

This video originally premiered on May 13, 2025. Watch on StockCharts’ dedicated David Keller page!

Previously recorded videos from Dave are available at this link.